Experiencing Tingling, Numbness, and pain?

Reverse nerve damage caused by diabetic neuropathy

  • Addresses the cause instead of simply masking the symptoms

  • Experience long term relief without the dangerous side effects of hydrocodone, lyrica, neurontin, and cymbalta

  • Cost effective, easy to use, and fast results - just one capsule a day with noticeable relief in as little as 60-90 days, and significant nerve damage repair in 6 months based on recent case studies

as seen on

What Others Are Saying

"I recommend Pre-Dx to my patients and family members as a way to obtain affordable and

comprehensive supplements to assist with a variety of medical issues. Much research in the areas of

elevated homocysteine and MTHFR gene mutation are currently being performed to evaluate how

they relate or impact chronic illnesses and neurological conditions. Pre-Dx is a way to incorporate

supplements that may potentially impact the regression and treatment of chronic illness and

neurological conditions...... and we have this available to us now. I take Pre-Dx daily and am a

satisfied customer. Personally, I feel it helps me to stay focused and increase my mental alertness."

- Dr. Julie B

5 Star Review

"Great product, great price. Quick shipping. Best product out there, especially for the price."

5 Star Review

"All good - service and product. My feet have not felt this good in years. I so remember nights I cried with pain in my toes and couldn't stand even a sheet over them. I keep getting more feeling back in my feet and so much more comfortable. May even have a little more energy that I can attribute to these pills. Thanks you for a good product at a reasonable price."

5 Star Review

"Great product with good measurable results. Great dealing with the owner - responds quickly to email."

5 Star Review

"I recommend Pre-DX to my patients and family as the most affordable and convenient supportive daily vitamin complex for general health maintenance and especially for common neurological disorders. It is the cornerstone vitamin supplement for all my patients with memory, balance and neuropathy problems. It was a very good day when this became available."

- Dr. P (Greenville, SC)

5 Star Review

As easy as 1 daily capsule

  • Take 1 capsule daily (or as directed by your doctor)

  • Give Pre-DX time to work – it took years to develop neuropathy, so it will take time to reverse the damage

  • Based on the data, patients improve from nerve damage to within normal ranges within 6 months.

  • Pre-DX can continue to restore nerve function the longer you take it.

"I rarely get to use the word “perplexed”, but the Vanderbilt doctor I saw this week who diagnosed me with ALS (Lou Gehrig’s disease) was perplexed that the muscles in my legs were not jumping as expected with ALS. Six weeks ago the nerves/muscles in my legs were visibly jumping every couple seconds.

I’ve dealt with neuropathy in my legs and feet for more than 20 years, and a few months ago Amanda Spence, The Holistic Collective, introduced me to your Pre-DX. On September 16th I started taking one pill daily, expecting it needed to build up in my system before I would notice anything. Last week I realized that the nerves/muscles weren’t jumping in my legs but didn't associate it with Pre-DX. It wasn’t until I was talking with a friend on the drive home from Vanderbilt that I realized Pre-DX was the reason. Thank you."

- PennY T.

5 Star Review

Address the root cause instead of masking the symptoms of Diabetic Nerve Damage

Science Backed

Pre-DX is the result of years of science backed studies. Data suggests that small nerve fiber and microvascular damage, oxidative stress, and inflammation starts well before symptoms occur. Overwhelming evidence recommends that we identify and address these conditions early and optimize nutritional support.

The Pre-DX Secret

The ingredients synergistically provide nutritional management of endothelial dysfunction associated with numbness, tingling, and the burning sensation in diabetes patients with neuropathy. Neurotrophic benefits come from improving endothelial dysfunction and maintaining blood flow in the vessels that carry important nutrients and oxygen to the peripheral nerves, resulting in nerve repair and regrowth.

key ingredients

Pre-DX contains the highest-grade L-methylfolate on the market, (Type C crystalline calcium salt - (6S)-5-Methyltetrahydrofolate), as well as 15 additional ingredients that work synergistically to fight against inflammation and oxidative stress and to improve overall health by directly targeting the root cause of the problem: inflammation and oxidative stress.

"Your product is so effective I now have my son taking it. Also, Joe Hunter is great at customer service!"

5 Star Review

"Great company to deal with. Great product at a great price."

5 Star Review

"It's always nice when you order Pre-Dx. The service is outstanding and so is it reps. No complaints at all. Very pleased."

5 Star Review

Single Bottle

(One Time Purchase)


$1 per serving

  • 60 servings in one bottle

  • 2 Month Supply

  • Ships once

  • Add 3 or more to your cart for a 10% discount

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Single Bottle

(Autoship Subscription)

$59.98 $53.99

$0.90 per serving

  • 60 servings in one bottle

  • 2 Month Supply delivered every 60 days

  • No commitment. Pause or Cancel any time

Best Value

Three Bottles

(Autoship Subscription)

$179.97 $152.97

$0.85 per serving

  • 180 servings in 3 bottles

  • 6 Month Supply delivered every 180 days

  • No commitment. Pause or Cancel any time

  • 60 servings per bottle

  • 2 Month Supply

  • Ships only once

  • $59.99 per bottle

  • $1 per serving

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100% Satisfaction "Empty Bottle" Guarantee

Use Pre-DX for a minimum of 60 - 90 days.

If you aren’t 100% satisfied, just email help@pre-dx.com and let us know. You will receive a complete refund of your purchase price.

You don’t need to send the product back -- You’re free to use the whole bottle until it’s 100% empty.

Although refunds are rare, most of our customers who do stop taking Pre-DX usually start back. Why? – Because they notice the difference!


Frequently Asked Questions (FAQ)

Why do I still have pain after taking Pre-DX?

Pre-DX is not a pain medication. It works on the underlying disease state by improving blood flow, allowing the nutrients to reach the damaged nerves. Data shows that patients that stay on Pre-DX for 6 months or more have improved nerve fiber density (repairing of the nerves). Stay on Pre-DX and give it a chance to work!

Why won’t my insurance cover this? 

Pre-DX is a nutraceutical that has pharmaceutical grade ingredients produced in a pharmaceutical production facility. We chose to go the route of nutraceutical to keep this cost affordable for patients

Can’t I just get something less expensive on Amazon? 

There are NO products like Pre-DX on Amazon. Also, none of the products on Amazon have doctor backed studies showing benefits. Remember that the most expensive product is the one that doesn’t work? If you pay $15 per month and it doesn’t work, isn’t that more expensive than a $30 product that works?

Why can’t I just get Pre-DX in my local pharmacy?

We did partner with some pharmacy companies but that increased the Pre-DX cost considerably but putting a middle person in the chain. We felt everybody deserved a quality of life and to live pain free. This can only happen by keeping

the price affordable. Therefore, we created our own mail order pharmacy. This way we can control the pricing and keep Pre-DX affordable.

How long do I need to take Pre-DX?

If you are a diabetic, this is a life-long medication or until your diabetes goes away. All diabetics have compromised blood flow, and increase inflammation and oxidative stress. Pre-DX is one of the best ways to combat that. People that

stop taking Pre-DX usually see their painful symptoms returning and start back on Pre-DX.

How do I know Pre-DX is right for me?

  • Pre-DX is perfect for you if you suffer from diabetic peripheral neuropathy and experience pain, numbness, and tingling in your hands and feet.

  • If you have recently been diagnosed with diabetes, you already have high levels of inflammation, and nerve damage has already begun. Pre-DX can help prevent you from getting to the painful state - neuropathy.

  • If you're age 50 or above, Pre-DX is an excellent multivitamin and nutraceutical that has all the necessary nutrients your body needs to maximize health. Most people in this age range have vitamin B12, Vitamin D, and Folate deficiency. Pre-DX is a vasodilator which improves blood flow and has many positive health benefits.

Proven Results Revealed in 107 Clinical Studies

The ingredients used in Pre-DX and their effects on the root cause of diabetic neuropathy have been heavily researched in over 100 clinical studies.

Pre-DX Clinical Case Study results

We have multiple case studies showing incredible results like this from Pre-DX

Measuring nerve density is how you clinically diagnose and determine the extent of damage from small fiber neuropathy. Higher nerve density is better, where > 10 nerve fibers per millimeter being considered the normal/acceptable range indicating no neuropathy damage. Here are the results from just two of our recent Pre-DX 6 month case studies.

Case Study #1: before

CASE STUDY #1: after

initial test results

Left Calf Epidermal Nerve Fiber Density:

2.5 nerve fibers/mm

Initial Result: Well below normal range

Right Calf Epidermal Nerve Fiber Density:

2.5 nerve fibers/mm

Initial Result: Well below normal range

followup test results

Left Calf Epidermal Nerve Fiber Density:

8.7 nerve fibers/mm (nearly normal range)

6 Month Result: +248% Fiber Density Increase

Right Calf Epidermal Nerve Fiber Density:

10.6 nerve fibers/mm (within normal range)

6 Month Result: +324% Fiber Density Increase

CASE STUDY #2: before

CASE STUDY #2: after

initial test results

Left Calf Epidermal Nerve Fiber Density:

7.18 nerve fibers/mm

Initial Result: Below normal range

Right Calf Epidermal Nerve Fiber Density:

14.0 nerve fibers/mm

Initial Result: Within normal range

followup test results

Left Calf Epidermal Nerve Fiber Density:

11.5 nerve fibers/mm (within normal range)

6 Month Result: +60.31% Fiber Density Increase

Right Calf Epidermal Nerve Fiber Density:

14.3 nerve fibers/mm (within normal range)

6 Month Result: +2.14% Fiber Density Increase

Ingredients & How Pre-DX Works

Ingredients & Science

These ingredients work synergistically to address the nutritional needs of patients with Diabetic Peripheral Neuropathy, Low B12, Low Vitamin D, Low Folate as well as support normal biological reactions essential to all cellular health.

Data suggests that small nerve fiber and microvascular damage, oxidative stress and inflammation starts well before symptoms occur. Overwhelming evidence recommends that we identify and address these conditions early and optimize nutritional support.

Pre-DX addresses endothelial dysfunction by increasing production of nitric oxide and increasing blood flow which allows essential nutrients to be transported to the nervous system and organs of the body.

Mechanism of Action

Pre-DX acts by optimizing intracellular antioxidants, and vitamins, so that impaired folate methylation is improved.  It is shown to restore efficiency of the conversion of homocysteine into methionine and reducing oxidative stress by increasing intracellular glutathione.

Major Key Ingredients

L-Methylfolate - Magnafolate-CTM [(6S)-5-methyltetrahydrofolic acid, Calcium salt C Crystal is needed for cell growth, amino acid metabolism, the formation of red and white blood cells, and proper cell division.

Pre-DX helps manage metabolic active folate deficiencies caused by certain medical conditions, MTHFR polymorphisms, and medications.  Individuals with some chronic illnesses, taking certain medications, or who have the genetic MTHFR deficiencies cannot efficiently metabolize dietary folate or folic acid into its bioactive form, L-methylfolate.

Alpha Lipoic Acid - Alpha-lipoic acid is an antioxidant and is taken for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. It seems to help prevent certain kinds of cell damage in the body. There is also evidence that alpha-lipoic acid can improve the function and conduction of neurons in diabetes.

Vitamin B12 - Is vital for neurological function, DNA production, and red blood cell development.

N-Acetyl Cysteine (NAC), Vitamin E & C - Antioxidants such as Vitamin E, C, and N-Acetylcysteine (NAC, a precursor to the body’s most powerful antioxidant - glutathione) are important synergistic dietary ingredients for protecting vascular tissue from oxidative damage.

Vitamin D - Its anti-inflammatory, antioxidant and neuroprotective properties support immune health, muscle function and brain cell activity. In animal models, Vitamin D deficiency has also been shown to impair the synthesis of folate transport protein necessary for folate absorption across the intestine.

Vitamin B6 - Pyridoxal-5-Phosphate - is involved in amino acid metabolism, red blood cell

production, and the creation of neurotransmitters.

Minor Ingredients:

B1 - Thiamine Hydrochloride plays an essential role in metabolism by helping

convert nutrients into energy.

B2 – Riboflavin - helps convert food into energy and acts as an antioxidant.

B3 – Niacin - plays a role in cellular signaling, metabolism, and DNA production and


B5 - Pantothenic acid - helps your body obtain energy from food and is also

involved in hormone and cholesterol production.

Zinc - plays a key role in skin health, immune function, and cell growth and may protect against acne, inflammation, and other conditions. Zinc is a nutrient that plays many vital roles in your body such as gene expression, enzymatic reactions, immune function, protein synthesis, DNA synthesis, wound healing, growth and development.

Other Synergistic Ingredients

Minerals - Selenium is a trace element that also functions as an antioxidant through the selenium-containing enzyme glutathione peroxidase, a vital antioxidant enzyme found in all cells with specific activity against hydrogen peroxide. Deficiencies in selenium have been associated with lowered activity of this antioxidant enzyme.

Challenges of Pre-diabetes

Nearly 80 million people are diagnosed with pre-diabetes or elevated A1C's and are non-symptomatic.  Most of these people are not taking anything to offset the already damaging effects taking place in the body such as inflammation and Oxidative Stress or changing their lifestyle to prevent the advancement to Type 2 diabetes. Pre-diabetes or elevated A1C's is the first stage of diabetes.

It is estimated that roughly 36% of people with pre-diabetes already have coronary artery disease, similar to the 42% with Type 2 diabetes and strikingly higher than the 21% with normal blood sugars. Higher than normal glucose levels impact hypertension (high blood pressure) and lipids like cholesterol and triglycerides. Most people with pre-diabetes show signs of Retinopathy (eye damage), Nephropathy (kidney damage) and Neuropathy (nerve damage), all diabetes complications.

Complications Associated with Prediabetes

  • Heart and blood vessel damage – heart attack, stroke, narrowing of the arteries and high blood pressure

  • Nerve damage – neuropathies, erectile dysfunction and digestive problems

  • Kidney Damage – nephropathy

  • Foot ulcerations – small cuts not healing due to lack of blood flow

  • Inflammation and Oxidative Stress – believed to be a precursor for all Diseases and Complications

Overwhelming data suggests that small nerve fiber and microvascular damage begins in Pre-diabetes.  Many Pre-diabetics are on Metformin which depletes B vitamins necessary to maintain proper nerve function.

Dosage and Administration

The recommended adult dose of Pre-DX is 1 capsule orally per day (with a meal) or as recommended by your health care practitioner.  Pre-DX is not recommended for use with children under 18 or during pregnancy.  


Pre-DX is contraindicated in patients with known hypersensitivity to any of the components contains in this product.  Pre-DX contains folate, which may interact with certain drugs that interfere with folate absorption or metabolism of homocysteine. Consult your healthcare professional (e.g., doctor or pharmacist) for more information.  If you are pregnant or breastfeeding, check with a doctor before taking Pre-DX.  

Adverse Effects

Allergic reactions to 5-MTHF are rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling, dizziness or trouble breathing. Nausea, vomiting, headache, other gastrointestinal symptoms, and rash have been associated with NAC.  There are rare reports of renal stone formations with NAC.

About Southeastern Healthcare Consultants, LLC

The owners of Pre-DX have over 40 years of combined experience and extensive research in the medical industry. Our experience is mainly around the benefits of vitamin supplementation, diabetic neuropathy, and complications associated with diabetes.

One area we identified as missing was in the field of early detection, and intervention. We took our experience and knowledge, hired a consulting team and developed a supplement that not only promotes good health but based on data, has been shown to reverse the damage caused by diabetic neuropathy.

Our goal when developing Pre-DX was to create an affordable product that works! Not just relieves the pain but reverses the damage caused by diabetes.

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