Experiencing Tingling, Numbness, and pain?
Reverse nerve damage caused by diabetic neuropathy
Addresses the cause instead of simply masking the symptoms
Experience long term relief without the dangerous side effects of hydrocodone, lyrica, neurontin, and cymbalta
Cost effective, easy to use, and fast results - just one capsule a day with noticeable relief in as little as 60-90 days, and significant nerve damage repair in 6 months based on recent case studies
as seen on
What Others Are Saying
"I recommend Pre-Dx to my patients and family members as a way to obtain affordable and
comprehensive supplements to assist with a variety of medical issues. Much research in the areas of
elevated homocysteine and MTHFR gene mutation are currently being performed to evaluate how
they relate or impact chronic illnesses and neurological conditions. Pre-Dx is a way to incorporate
supplements that may potentially impact the regression and treatment of chronic illness and
neurological conditions...... and we have this available to us now. I take Pre-Dx daily and am a
satisfied customer. Personally, I feel it helps me to stay focused and increase my mental alertness."
- Dr. Julie B
"Great product, great price. Quick shipping. Best product out there, especially for the price."
"All good - service and product. My feet have not felt this good in years. I so remember nights I cried with pain in my toes and couldn't stand even a sheet over them. I keep getting more feeling back in my feet and so much more comfortable. May even have a little more energy that I can attribute to these pills. Thanks you for a good product at a reasonable price."
"Great product with good measurable results. Great dealing with the owner - responds quickly to email."
"I recommend Pre-DX to my patients and family as the most affordable and convenient supportive daily vitamin complex for general health maintenance and especially for common neurological disorders. It is the cornerstone vitamin supplement for all my patients with memory, balance and neuropathy problems. It was a very good day when this became available."
- Dr. P (Greenville, SC)
As easy as 1 daily capsule
Take 1 capsule daily (or as directed by your doctor)
Give Pre-DX time to work – it took years to develop neuropathy, so it will take time to reverse the damage
Based on the data, patients improve from nerve damage to within normal ranges within 6 months.
Pre-DX can continue to restore nerve function
"I rarely get to use the word “perplexed”, but the Vanderbilt doctor I saw this week who diagnosed me with ALS (Lou Gehrig’s disease) was perplexed that the muscles in my legs were not jumping as expected with ALS. Six weeks ago the nerves/muscles in my legs were visibly jumping every couple seconds.
I’ve dealt with neuropathy in my legs and feet for more than 20 years, and a few months ago Amanda Spence, The Holistic Collective, introduced me to your Pre-DX. On September 16th I started taking one pill daily, expecting it needed to build up in my system before I would notice anything. Last week I realized that the nerves/muscles weren’t jumping in my legs but didn't associate it with Pre-DX. It wasn’t until I was talking with a friend on the drive home from Vanderbilt that I realized Pre-DX was the reason. Thank you."
- PennY T.
Address the root cause instead of masking the symptoms of Diabetic Nerve Damage
Science Backed
Pre-DX is the result of years of science backed studies. Data suggests that small nerve fiber and microvascular damage, oxidative stress, and inflammation starts well before symptoms occur. Overwhelming evidence recommends that we identify and address these conditions early and optimize nutritional support.
The Pre-DX Secret
The ingredients synergistically provide nutritional management of endothelial dysfunction associated with numbness, tingling, and the burning sensation in diabetes patients with neuropathy. Neurotrophic benefits come from improving endothelial dysfunction and maintaining blood flow in the vessels that carry important nutrients and oxygen to the peripheral nerves, resulting in nerve repair and regrowth.
key ingredients
Pre-DX contains the highest-grade L-methylfolate on the market, (Type C crystalline calcium salt - (6S)-5-Methyltetrahydrofolate), as well as 15 additional ingredients that work synergistically to fight against inflammation and oxidative stress and to improve overall health by directly targeting the root cause of the problem: inflammation and oxidative stress.
"Your product is so effective I now have my son taking it. Also, Joe Hunter is great at customer service!"
"Great company to deal with. Great product at a great price."
"It's always nice when you order Pre-Dx. The service is outstanding and so is it reps. No complaints at all. Very pleased."
Single Bottle
(One Time Purchase)
$59.99
$1 per serving
60 servings in one bottle
2 Month Supply
Ships once
Add 3 or more to your cart for a 10% discount
Most Popular
Single Bottle
(Autoship Subscription)
$59.98 $53.99
$0.90 per serving
60 servings in one bottle
2 Month Supply delivered every 60 days
No commitment. Pause or Cancel any time
Best Value
Three Bottles
(Autoship Subscription)
$179.97 $152.97
$0.85 per serving
180 servings in 3 bottles
6 Month Supply delivered every 180 days
No commitment. Pause or Cancel any time
60 servings per bottle
2 Month Supply
Ships only once
$59.99 per bottle
$1 per serving
Order Pre-DX (One Time Purchase)
Use the form above for a one-time purchase OR
100% Satisfaction "Empty Bottle" Guarantee
Use Pre-DX for a minimum of 60 days.
If you aren’t 100% satisfied, just email help@pre-dx.com and let us know. You will receive a complete refund of your purchase price.
You don’t even need to send the product back -- You’re free to use the whole bottle until it’s 100% empty.
Although refunds are rare, most of our customers who do stop taking Pre-DX usually start back. Why? – Because they notice the difference!
Frequently Asked Questions (FAQ)
Why do I still have pain after taking Pre-DX?
Pre-DX is not a pain medication. It works on the underlying disease state by improving blood flow, allowing the nutrients to reach the damaged nerves. Data shows that patients that stay on Pre-DX for 6 months or more have improved nerve fiber density (repairing of the nerves). Stay on Pre-DX and give it a chance to work!
Why won’t my insurance cover this?
Pre-DX is a nutraceutical that has pharmaceutical grade ingredients produced in a pharmaceutical production facility. We chose to go the route of nutraceutical to keep this cost affordable for patients
Can’t I just get something less expensive on Amazon?
There are NO products like Pre-DX on Amazon. Also, none of the products on Amazon have doctor backed studies showing benefits. Remember that the most expensive product is the one that doesn’t work? If you pay $15 per month and it doesn’t work, isn’t that more expensive than a $30 product that works?
Why can’t I just get Pre-DX in my local pharmacy?
We did partner with some pharmacy companies but that increased the Pre-DX cost considerably but putting a middle person in the chain. We felt everybody deserved a quality of life and to live pain free. This can only happen by keeping
the price affordable. Therefore, we created our own mail order pharmacy. This way we can control the pricing and keep Pre-DX affordable.
How long do I need to take Pre-DX?
If you are a diabetic, this is a life-long medication or until your diabetes goes away. All diabetics have compromised blood flow, and increase inflammation and oxidative stress. Pre-DX is one of the best ways to combat that. People that
stop taking Pre-DX usually start back as they see their painful symptoms returning.
How do I know Pre-DX is right for me?
Pre-DX is perfect for you if you suffer from diabetic peripheral neuropathy and experience pain, numbness, and tingling in your hands and feet.
If you are pre-diabetic, or have been recently diagnosed with diabetes, you already have high levels of inflammation, and nerve damage has already begun before symptoms are present. Pre-DX
can help prevent you from ever getting to the painful state.
If you're age 50 or above, Pre-DX is an excellent multivitamin and nutraceutical that has all the necessary nutrients your body needs to maximize health. Most people in this age range have vitamin B12, Vitamin D, and Folate deficiency. Pre-DX is a vasodilator which improves blood flow and has many positive health benefits.
Proven Results Revealed in 107 Clinical Studies
The ingredients used in Pre-DX and their effects on the root cause of diabetic neuropathy have been heavily researched in over 100 clinical studies.
Pre-DX Clinical Case Study results
We have multiple case studies showing incredible results like this from Pre-DX
Measuring nerve density is how you clinically diagnose and determine the extent of damage from small fiber neuropathy. Higher nerve density is better, where > 10 nerve fibers per millimeter being considered the normal/acceptable range indicating no neuropathy damage. Here are the results from two of our Pre-DX 6 month case studies.
Case Study #1: before
CASE STUDY #1: after
initial test results
Left Calf Epidermal Nerve Fiber Density:
2.5 nerve fibers/mm
Initial Result: Well below normal range
Right Calf Epidermal Nerve Fiber Density:
2.5 nerve fibers/mm
Initial Result: Well below normal range
followup test results
Left Calf Epidermal Nerve Fiber Density:
8.7 nerve fibers/mm (nearly normal range)
6 Month Result: +248% Fiber Density Increase
Right Calf Epidermal Nerve Fiber Density:
10.6 nerve fibers/mm (within normal range)
6 Month Result: +324% Fiber Density Increase
CASE STUDY #2: before
CASE STUDY #2: after
initial test results
Left Calf Epidermal Nerve Fiber Density:
7.18 nerve fibers/mm
Initial Result: Below normal range
Right Calf Epidermal Nerve Fiber Density:
14.0 nerve fibers/mm
Initial Result: Within normal range
followup test results
Left Calf Epidermal Nerve Fiber Density:
11.5 nerve fibers/mm (within normal range)
6 Month Result: +60.31% Fiber Density Increase
Right Calf Epidermal Nerve Fiber Density:
14.3 nerve fibers/mm (within normal range)
6 Month Result: +2.14% Fiber Density Increase
Ingredients + How Pre-DX Works
Ingredients & Science
These ingredients work synergistically to address the nutritional needs of patients with Diabetic Peripheral Neuropathy, Low B12, Low Vitamin D, Low Folate as well as support normal biological reactions essential to all cellular health.
Pre-DX was designed to address the damaging effects of Neuropathy and Pre-Diabetes as well as protect against inflammation and oxidative stress, improving your body's overall health.
Data suggests that small nerve fiber and microvascular damage, oxidative stress and inflammation starts well before symptoms occur. Overwhelming evidence recommends that we identify and address these conditions early and optimize nutritional support.
Pre-DX addresses endothelial dysfunction by increasing production of nitrous oxide and increasing blood flow which allows essential nutrients to be transported to the nervous system and organs of the body.
Mechanism of Action
Pre-DX acts by optimizing intracellular antioxidants, and vitamins, so that impaired folate methylation is improved. It is shown to restore efficiency of the conversion of homocysteine into methionine and reducing oxidative stress by increasing intracellular glutathione.
Key Ingredients
Magnafolate-CTM [(6S)-5-methyltetrahydrofolic acid, Calcium salt C Crystal (L-Methylfolate)]
Pre-DX contains a proprietary blend of vitamins and minerals shown to help manage metabolic active folate deficiencies caused by certain medical conditions, MTHFR polymorphisms, and medications. Individuals with some chronic illnesses, taking certain medications, or who have the genetic MTHFR deficiencies cannot efficiently metabolize dietary folate or folic acid into its bioactive form, L-methylfolate. This step is required to maximize health.
Clinical studies have concluded that direct supplementation with L-methylfolate increases plasma folate levels more effectively than folic acid, especially in those with MTHFR genetic variations.
B-Vitamins
B1 - Thiamine Hydrochloride plays an essential role in metabolism by helping
convert nutrients into energy.
B2 – Riboflavin - helps convert food into energy and acts as an antioxidant.
B3 – Niacin - plays a role in cellular signaling, metabolism, and DNA production and
repair.
B5 - Pantothenic acid - helps your body obtain energy from food and is also
involved in hormone and cholesterol production.
B6 – Pyridoxal-5-Phosphate - is involved in amino acid metabolism, red blood cell
production, and the creation of neurotransmitters.
B9 – L-Methylfolate - is needed for cell growth, amino acid metabolism, the
formation of red and white blood cells, and proper cell division.
B12 – Methylcobalamin - is vital for neurological function, DNA production, and red
blood cell development.
Vitamin D
Its anti-inflammatory, antioxidant and neuroprotective properties support immune health, muscle function and brain cell activity. In animal models, Vitamin D deficiency has also been shown to impair the synthesis of folate transport protein necessary for folate absorption across the intestine.
Zinc
Zinc plays a key role in skin health, immune function, and cell growth and may protect against acne, inflammation, and other conditions. Zinc is a nutrient that plays many vital roles in your body such as gene expression, enzymatic reactions, immune function, protein synthesis, DNA synthesis, wound healing, growth and development.
Other Synergistic Ingredients
Vitamins and N-Acetyl Cysteine
Antioxidants such as Vitamin E, C, and N-Acetylcysteine (NAC, a precursor of the body’s natural glutathione) are important synergistic dietary ingredients for protecting vascular tissue from oxidative damage. Pantothenic acid (sometimes referred to as Vitamin B5) is found in the body in the form of Coenzyme A (CoA), which is involved in the synthesis of glutathione. Vitamin B1 (Thiamine) also indirectly acts as an antioxidant.
Alpha Lipoic Acid
Alpha-lipoic acid is a vitamin-like chemical called an antioxidant and is taken for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. Alpha-lipoic acid seems to help prevent certain kinds of cell damage in the body, and restores vitamin levels such as vitamin E and vitamin C. There is also evidence that alpha-lipoic acid can improve the function and conduction of neurons in diabetes.
Minerals
Selenium is a trace element that also functions as an antioxidant through the selenium-containing enzyme glutathione peroxidase, a vital antioxidant enzyme found in all cells with specific activity against hydrogen peroxide. Deficiencies in selenium have been associated with lowered activity of this antioxidant enzyme.
Dosage and Administration
The recommended adult dose of Pre-DX is 1 capsule orally per day (with a meal) or as recommended by your health care practitioner. Pre-DX is not recommended for use with children or during pregnancy.
Contraindications
Pre-DX is contraindicated in patients with known hypersensitivity to any of the components contains in this product. Pre-DX contains folate, which may interact with certain drugs that interfere with folate absorption or metabolism of homocysteine. Consult your healthcare professional (e.g., doctor or pharmacist) for more information. If you are pregnant or breastfeeding, check with a doctor before using Pre-DX.
Adverse Effects
Allergic reactions to 5-MTHF are rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling, dizziness or trouble breathing. Nausea, vomiting, headache, other gastrointestinal symptoms, and rash have been associated with NAC. There are rare reports of renal stone formations with NAC.
Bioactive form of Folate
Pre-DX contains 2.5 mg of the bioactive form of folate, L-Methylfolate (L-5-Methyltetrahydrofolate Calcium C Crystal), as well as 15 other ingredients to address the nutritional needs of patients with pre-diabetes, diabetes or diabetic neuropathy. Many of the ingredients are in the bioactive form so they can bypass genetic mutations allowing
the body to readably absorb and use the nutrients necessary. Pre-DX can help fight against inflammation and oxidative stress; two risk factors associated with diabetes.
Challenges of Pre-diabetes
Nearly 80 million people are diagnosed with pre-diabetes or elevated A1C's and are non-symptomatic. Most of these people are not taking anything to offset the already damaging effects taking place in the body - Inflammation and Oxidative Stress or changing their lifestyle to prevent the advancement to Type 2 diabetes. Pre-diabetes or elevated A1C's is the first stage of diabetes.
It is estimated that roughly 36% of people with pre-diabetes already have coronary artery disease, similar to the 42% with Type 2 diabetes and strikingly higher than the 21% with normal blood sugars. Higher than normal glucose levels impact hypertension (high blood pressure) and lipids like cholesterol and triglycerides. Most people with pre-diabetes show signs of Retinopathy (eye damage), Nephropathy (kidney damage) and Neuropathy (nerve damage), all diabetes complications.
Pre-diabetes Facts:
37 – 38% of US Adults are considered Pre-diabetic, roughly 86 million – and growing
Pre-diabetes is where inflammation, oxidative stress and nerve damage may begin – long before symptoms are identified
Individuals with pre-diabetes have poorer quality of life and a shorter life span
Diabetes remains one of the leading causes of death in the United States
Addressing pre-diabetes can have substantial savings on the health care system.
Diabetes cost the U.S. medical system $245 billion in 2012.
Complications Associated with Prediabetes
Heart and blood vessel damage – heart attack, stroke, narrowing of the arteries and high blood pressure
Nerve damage – neuropathies, erectile dysfunction and digestive problems
Kidney Damage – nephropathy
Foot ulcerations – small cuts not healing due to lack of blood flow
Inflammation and Oxidative Stress – believed to be a precursor for all Diseases and Complications
Overwhelming data suggests that small nerve fiber and microvascular damage begins in Pre-diabetes. Many Pre-diabetics are on Metformin which depletes B vitamins necessary to maintain proper nerve function.
About Southeastern Healthcare Consultants, LLC
We have over 40 years of combined experience and extensive research in the medical industry. Our experience is around the benefits of vitamin supplementation, diabetic neuropathy, and complications associated with diabetes.
One area we identified as missing was in the field of early detection, and intervention. We took our experience and knowledge and developed a supplement that not only promotes good health but based on data, has been shown to reverse the damage caused by diabetic neuropathy.
If we can help assist our practitioners with a product that is safe, affordable and easily
accessible, we believe we can improve the patient’s quality of life.
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